Cancer Chemopreventive Activity of Odorine and Odorinol from Aglaia odorata

In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constitue...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2001, Vol.24(11), pp.1282-1285
Main Authors: INADA, Akira, NISHINO, Hoyoku, KUCHIDE, Masashi, TAKAYASU, Junko, MUKAINAKA, Teruo, NOBUKUNI, Yoshitaka, OKUDA, Masato, TOKUDA, Harukuni
Format: Article
Language:English
Subjects:
Aglaia odorata
aminopyrrolidine-diamide
Animals
anti-carcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - therapeutic use
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogenicity Tests - methods
Drug Evaluation, Preclinical - methods
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - therapeutic use
Female
Foods and miscellaneous
Medical sciences
Meliaceae - chemistry
Mice
Mice, Inbred SENCAR
odorine
odorinol
Papilloma - chemically induced
Papilloma - prevention & control
Phytotherapy - methods
Plant Leaves - chemistry
Pyrrolidines - chemistry
Pyrrolidines - isolation & purification
Pyrrolidines - therapeutic use
Skin Neoplasms - chemically induced
Skin Neoplasms - prevention & control
Tumors
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Summary:In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.24.1282