Natural trans-Crotonin

The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with anoth...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2002-04, Vol.25 (4), p.452
Main Authors: Akiko Hiruma-Lima, Clélia, Toma, Walber, de Souza Gracioso, Juliano, Beatriz Albino de Almeida, Ana, Maria Batista, Leônia, Magri, Luciana, Cláudia Bensuaski de Paula, Ana, Rocha Soares, Fernanda, Sávio Nunes, Domingos, Regina Monteiro Souza Brito, Alba
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Language:English
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Summary:The nor-clerodane diterpene trans-crotonin isolated from the bark of Croton cajucara BENTH. was investigated for its ability to prevent the formation of gastric-mucosa ulceration in different experimental models in mice. The results obtained from crotonin were compared with those obtained with another diterpene, DHC (trans-dehydrocrotonin) in the same models. When previously administered (p.o.) at the dose of 100 mg/kg, crotonin, as well as DHC, significantly reduced (p
ISSN:0918-6158
1347-5215