Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Adrenocorticotropic Hormone (ACTH) and Catecholamine Levels in Plasma of Experimental Menopausal Model Rats

To investigate the effectiveness of benzyl β-D-glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Prunus mume, for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2004, Vol.27(1), pp.136-137
Main Authors: Ina, Hiroji, Yamada, Kenji, Matsumoto, Kosai, Miyazaki, Toshio
Format: Article
Language:English
Subjects:
adrenocorticotropic hormone (ACTH) level
Adrenocorticotropic Hormone - blood
Animals
Antioxidants - pharmacology
benzyl β-D-glucopyranoside
Caffeic Acids - pharmacology
catecholamine level
Catecholamines - blood
chlorogenic acid
Chlorogenic Acid - isolation & purification
Chlorogenic Acid - pharmacology
Cinnamates - pharmacology
Depsides
Dose-Response Relationship, Drug
ether stress
Female
Fruit - chemistry
Glucosides - isolation & purification
Glucosides - pharmacology
Ovariectomy
Prunus - chemistry
Prunus mume
Quinic Acid - pharmacology
Rats
Rosmarinic Acid
Sexual Maturation - physiology
Stress, Psychological - metabolism
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Summary:To investigate the effectiveness of benzyl β-D-glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Prunus mume, for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and catecholamine (adrenaline, noradrenaline, and dopamine) levels were examined in the plasma of M-rats. Caffeic acid, quinic acid, and rosmarinic acid, which are compounds structurally related to CA, were also examined. BG obviously recovered catecholamine levels decreased by ether stress and increased dopamine to high levels. On the other hand, CA significantly decreased the ACTH level increased by ether stress and showed the greatest effect of all compounds. These results suggest that BG and CA may contribute to relieving the tension in M-rats caused by ether stress.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.27.136