Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure

We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl4) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance (CLtot) in CCl4-treated rats, while the steady-state volume of distribution (Vdss) was...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2005, Vol.28(3), pp.556-559
Main Authors: Konishi, Hiroki, Sudo, Masatomo, Sumi, Masaki, Morii, Hiroaki, Minouchi, Tokuzo, Aimoto, Tachio, Yamaji, Akira
Format: Article
Language:English
Subjects:
acute hepatic failure rat
Animals
carbon tetrachloride
Carbon Tetrachloride - toxicity
Echinocandins
elimination clearance
Injections, Intravenous
Lipopeptides
Lipoproteins - administration & dosage
Lipoproteins - blood
Lipoproteins - pharmacokinetics
Liver Failure, Acute - blood
Liver Failure, Acute - chemically induced
Male
Micafungin
micafungin pharmacokinetics
Peptides, Cyclic - administration & dosage
Peptides, Cyclic - blood
Peptides, Cyclic - pharmacokinetics
Rats
Rats, Sprague-Dawley
Tissue Distribution
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Summary:We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl4) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance (CLtot) in CCl4-treated rats, while the steady-state volume of distribution (Vdss) was significantly increased by CCl4 treatment. Alteration in the serum unbound fraction of micafungin after CCl4 treatment was unlikely in light of the serum albumin, bilirubin, creatinine, and urea nitrogen. The increased Vdss was attributable to augmentation in the accessibility of micafungin to peripheral tissue without impairment of the intrinsic clearance, because slight enhancement of the tissue distribution of micafungin was confirmed following CCl4 treatment.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.556