The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats

Statin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has an anti-inflammatory effect. The aim of this study was to investigate the effect of Lovastatin (statin) on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats. In statin treated group, the pancreas...

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Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(8), pp.1394-1397
Main Authors: Choi, Ok-Sun, Park, Sung-Joo, Seo, Sang-Wan, Park, Cheung-Seog, Cho, Jeong-Je, Ahn, Hyun-Jong
Format: Article
Language:English
Subjects:
Acute Disease
acute pancreatitis
Animals
anti-inflammatory effect
Cholecystokinin - toxicity
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Interleukin-1 - metabolism
Interleukin-6 - metabolism
Lipase - metabolism
Lovastatin - therapeutic use
Male
Pancreatitis - chemically induced
Pancreatitis - drug therapy
Pancreatitis - enzymology
Pancreatitis - metabolism
Rats
Rats, Wistar
statin
Tumor Necrosis Factor-alpha - metabolism
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description Statin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has an anti-inflammatory effect. The aim of this study was to investigate the effect of Lovastatin (statin) on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis in rats. In statin treated group, the pancreas weight/body weight (pw/bw) ratio in CCK-induced acute pancreatitis was significantly lower than DMSO-treated group. Statin also increased the pancreatic level of HSP 60. Additionally, the secretions of IL-1β, TNF-α and IL-6 and the lipase levels were decreased in statin treated group. These results suggest that statin may play an important role in mitigating the progression of the inflammatory reactions during acute pancreatitis.
doi_str_mv 10.1248/bpb.28.1394
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subjects Acute Disease
acute pancreatitis
Animals
anti-inflammatory effect
Cholecystokinin - toxicity
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Interleukin-1 - metabolism
Interleukin-6 - metabolism
Lipase - metabolism
Lovastatin - therapeutic use
Male
Pancreatitis - chemically induced
Pancreatitis - drug therapy
Pancreatitis - enzymology
Pancreatitis - metabolism
Rats
Rats, Wistar
statin
Tumor Necrosis Factor-alpha - metabolism
title The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats
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