Effect of Gender on Theophylline Clearance in the Asthmatic Acute Phase in Japanese Pediatric Patients

The effect of gender on theophylline clearance was investigated retrospectively in 96 Japanese pediatric patients (63 males and 33 females) ranging in age from 0.5 to 8 years and in weight from 6.3 to 36.8 kg. All patients received intravenous constant-rate infusion of aminophylline in the asthmatic...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2009/02/01, Vol.32(2), pp.304-307
Main Authors: Igarashi, Tsutomu, Iwakawa, Seigo
Format: Article
Language:English
Subjects:
Acute Disease
Aging - metabolism
Anti-Asthmatic Agents - pharmacokinetics
Anti-Asthmatic Agents - therapeutic use
Anti-Inflammatory Agents - pharmacology
Asthma - drug therapy
Asthma - metabolism
Child
Child, Preschool
clearance
Drug Interactions
Female
Fluorescence Polarization Immunoassay
gender difference
Humans
Infant
Japanese child
Male
Oxygen Consumption - physiology
pharmacokinetics
Prednisolone - pharmacology
Sex Characteristics
Terbutaline - pharmacology
theophylline
Theophylline - pharmacokinetics
Theophylline - therapeutic use
therapeutic drug monitoring
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Summary:The effect of gender on theophylline clearance was investigated retrospectively in 96 Japanese pediatric patients (63 males and 33 females) ranging in age from 0.5 to 8 years and in weight from 6.3 to 36.8 kg. All patients received intravenous constant-rate infusion of aminophylline in the asthmatic acute phase. The theophylline clearances in males and females were 56.2±15.4 and 50.1±14.2 ml/h/kg for ages 0.5—
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.32.304