Synergistic Antioxidant Activities of Eight Traditional Chinese Herb Pairs

Many Chinese therapeutic herbs that are traditionally used in combination demonstrate significantly better pharmacological effects when used in the combination than when used alone. However, the pharmacological mechanism for this synergism is still not well understood. In the present study, the anti...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2009/06/01, Vol.32(6), pp.1021-1026
Main Authors: Yang, Wen-Jian, Li, Da-Peng, Li, Jin-Kui, Li, Ming-Hua, Chen, Yi-Lun, Zhang, Pei-Zheng
Format: Article
Language:English
Subjects:
antioxidant capability
Biphenyl Compounds - chemistry
Drug Synergism
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
flavonoid
Flavonoids - isolation & purification
Free Radical Scavengers - chemistry
Free Radical Scavengers - pharmacology
herb pair
Hydroxyl Radical - chemistry
phenolic
Phenols - isolation & purification
Picrates - chemistry
Superoxides - chemistry
synergistic effect
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Summary:Many Chinese therapeutic herbs that are traditionally used in combination demonstrate significantly better pharmacological effects when used in the combination than when used alone. However, the pharmacological mechanism for this synergism is still not well understood. In the present study, the antioxidant activities of six herbs ((Paeonia lactiflora (PL), Atractylodes macrocephala (AMA), Angelica sinensis (AS), Astragalus membranaceus (AME), Glycyrrhiza uralensis (GU) and Rheum officinale (RO)), which were historically combined into eight traditional Chinese herb pairs (TCHPs) (AME-AS, AME-AMA, AME-RO, AME-GU, AME-PL, PL-AS, PL-AMA and PL-GU), were investigated in vitro by assessing the 1,1-diphenyl-2-picryl hydrazine (DPPH)-radical scavenging abilities of the herbs. The results of this study showed that all eight TCHPs had a significantly larger scavenging capacity than would be expected from the theoretical sum of those of the respective constituent herbs (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.32.1021