H2 Receptor-Mediated Positive Inotropic Effect of Histamine in Neonatal Guinea-Pig Left Atria

The receptor type mediating the positive inotropic effect of histamine was examined in left atria from neonatal guinea pigs. The positive inotropic effect of histamine, as well as its action potential prolonging effect, was antagonized by ranitidine, but not by chlorpheniramine or thiperamide. The p...

Full description

Saved in:
Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2010/12/01, Vol.33(12), pp.2033-2035
Main Authors: Agata, Naoki, Kato, Yoshimitsu, Namekata, Iyuki, Takahara, Akira, Tanaka, Hikaru, Chino, Daisuke, Koike, Katsuo, Tanaka, Yoshio
Format: Article
Language:English
Subjects:
guinea-pig
histamine
inotropy
left atrium
neonate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The receptor type mediating the positive inotropic effect of histamine was examined in left atria from neonatal guinea pigs. The positive inotropic effect of histamine, as well as its action potential prolonging effect, was antagonized by ranitidine, but not by chlorpheniramine or thiperamide. The positive inotropic effect was enhanced by isobutylmethylxantine. Receptor binding studies revealed the presence of both H1 and H2 receptor types. These results suggest that the positive inotropic effect of histamine in the neonatal guinea-pig atrium is mediated by H2 receptors.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.33.2033