Synthesis and Biological Activities of Ferulic Acid-Amino Acid Derivatives

Three series of ferulic acid derivatives (feruloylaminoacid benzyl ester or methyl ester, feruloylaminoacid, and 4-O-[N-carbobenzyloxy)-aminoacyl]ferulic acid) were synthesized newly, and their superoxide dismutase (SOD)-like, platelet aggregation (PA)-in-hibitory, tyrosinase-inhibitory,, and angiot...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997, Vol.61 (3), p.527-529
Main Authors: Miao, Zhuang, Kayahara, Hiroshi, Tadasa, Koji
Format: Article
Language:English
Subjects:
angiotensin converting enzyme
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
ferulic acid-amino acid derivatives
Medical sciences
Pharmacology. Drug treatments
platelet aggregation
superoxide radical
tyrosinase
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Summary:Three series of ferulic acid derivatives (feruloylaminoacid benzyl ester or methyl ester, feruloylaminoacid, and 4-O-[N-carbobenzyloxy)-aminoacyl]ferulic acid) were synthesized newly, and their superoxide dismutase (SOD)-like, platelet aggregation (PA)-in-hibitory, tyrosinase-inhibitory,, and angiotensin converting enzyme (ACE)-inhibitory activities were evaluated. 4-O-[N-(Carbobenzyloxy)isoleucyl]ferulic acid (20) and 4-O-[N-(carbobenzyloxy)prolyl]ferulic acid (21) showed potent PA-inhibitory activities and tyrosinase-inhibitory activities, while they also had SOD-like activities at the same level as ferulic acid.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.61.527