Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrolne P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to felnale BALB/c mice four times every other day by intraperitoneal injection....

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-07, Vol.66 (7), p.1610-1614
Main Authors: Hashimoto, T. (Kobe Univ. (Japan)), Nonaka, Y, Minato, K, Kawakami, S, Mizuno, M, Fukuda, I, Kanazawa, K, Ashida, H
Format: Article
Language:English
Subjects:
Agaricales - chemistry
AGARICUS
Agaricus - chemistry
Agaricus blazei
Agaricus blazei polysaccharides
Animals
Biological and medical sciences
Body Weight - drug effects
Cytochrome P-450 CYP1A1 - antagonists & inhibitors
Cytochrome P-450 CYP1A1 - biosynthesis
Cytochrome P-450 CYP1A1 - genetics
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System - biosynthesis
CYTOCHROME P450
Female
Gene Expression Regulation, Enzymologic - drug effects
Immunomodulators
lentinan
Lentinan - pharmacology
Lentinas edodes
Lentinula - chemistry
LENTINULA EDODES
Lentinus edodes
Medical sciences
Methylcholanthrene - pharmacology
MICE
Mice, Inbred BALB C
Organ Size - drug effects
Pharmacology. Drug treatments
POLYSACCHARIDES
Polysaccharides - pharmacology
tumor necrosis factor-α (TNF-α)
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Summary:To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrolne P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to felnale BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.66.1610