Heteroatom-containing antibacterial phenolic metabolites from a terrestrial Ampelomyces fungus

Two new sulfur-containing phenolic compounds, 7-hydroxy-5-hydroxymethyl-2H-benzo[1,4]thiazin-3-one (1) and 2,5-dihydroxy-3-methanesulfinylbenzyl alcohol (2), along with two known compounds, 3-chloro-2,5dihydroxybenzyl alcohol (3) and 2-hydroxy-6-methylbenzoic acid (4), were isolated from the mycelia...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-07, Vol.72 (7), p.1746-1749
Main Authors: Zhang, H.(Chinese Academy of Sciences, Guangzhou (China). South China Botanical Garden), Xie, H, Qiu, S.X, Xue, J, Wei, X
Format: Article
Language:English
Subjects:
AMPELOMYCES
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
antibacterial activity
ANTIBIOTICOS
ANTIBIOTICS
ANTIBIOTIQUE
BACTERIA
Bacteria - drug effects
Biological and medical sciences
Biological Products
COMPOSE PHENOLIQUE
COMPUESTOS FENOLICOS
ESPECTROSCOPIA RMN
filamentous fungus
Fundamental and applied biological sciences. Psychology
fungal secondary metabolites
Fungi - chemistry
Inhibitory Concentration 50
METABOLITE SECONDAIRE
METABOLITOS SECUNDARIOS
MICELIO
Molecular Structure
MYCELIUM
NMR SPECTROSCOPY
PHENOLIC COMPOUNDS
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
SECONDARY METABOLITES
SPECTROSCOPIE RMN
Spectrum Analysis
sulfur-containing phenol
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Summary:Two new sulfur-containing phenolic compounds, 7-hydroxy-5-hydroxymethyl-2H-benzo[1,4]thiazin-3-one (1) and 2,5-dihydroxy-3-methanesulfinylbenzyl alcohol (2), along with two known compounds, 3-chloro-2,5dihydroxybenzyl alcohol (3) and 2-hydroxy-6-methylbenzoic acid (4), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus by antibacterial assay-guided fractionation. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1-3 showed structure and microbial dependent antibacterial activities.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.80043