Diffusion-weighted MR imaging in primary rectal cancer staging demonstrates but does not characterise lymph nodes

• Published in: European radiology 2013-12, Vol.23 (12), p.3354-3360
• Main Authors: Heijnen, Luc A., Lambregts, Doenja M. J., Mondal, Dipanjali, Martens, Milou H., Riedl, Robert G., Beets, Geerard L., Beets-Tan, Regina G. H.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Area Under Curve; Colorectal cancer; Diagnostic Radiology; Diffusion Magnetic Resonance Imaging - methods; Female; Humans; Imaging; Internal Medicine; Interventional Radiology; Lymph Nodes - pathology; Lymphatic Metastasis; Lymphatic system; Magnetic Resonance; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Metastasis; Middle Aged; Neoplasm Staging; Neuroradiology; Performance evaluation; Radiation; Radiology; Rectal Neoplasms - pathology; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Sentinel Lymph Node Biopsy - methods; Surgery; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-013-2952-5

Objectives To evaluate the performance of diffusion-weighted MRI (DWI) for the detection of lymph nodes and for differentiating between benign and metastatic nodes during primary rectal cancer staging. Methods Twenty-one patients underwent 1.5-T MRI followed by surgery (± preoperative 5 × 5 Gy). Imaging consisted of T2-weighted MRI, DWI (b0, 500, 1000), and 3DT1-weighted MRI with 1-mm isotropic voxels. The latter was used for accurate detection and per lesion histological validation of nodes. Two independent readers analysed the signal intensity on DWI and measured the mean apparent diffusion coefficient (ADC) for each node (ADC node ) and the ADC of each node relative to the mean tumour ADC (ADC rel ). Results DWI detected 6 % more nodes than T2W-MRI. The signal on DWI was not accurate for the differentiation of metastatic nodes (AUC 0.45–0.50). Interobserver reproducibility for the nodal ADC measurements was excellent (ICC 0.93). Mean ADC node was higher for benign than for malignant nodes (1.15 ± 0.24 vs. 1.04 ± 0.22 *10 -3  mm 2 /s), though not statistically significant ( P  = 0.10). Area under the ROC curve/sensitivity/specificity for the assessment of metastatic nodes were 0.64/67 %/60 % for ADC node and 0.67/75 %/61 % for ADC rel . Conclusions DWI can facilitate lymph node detection, but alone it is not reliable for differentiating between benign and malignant lymph nodes. Key Points • Diffusion - weighted ( DW ) magnetic resonance imaging ( MRI ) offers new information in rectal cancer . • DW MRI demonstrates more lymph nodes than standard T2 - weighted MRI . • Visual DWI assessment does not discriminate between benign and metastatic nodes . • Apparent diffusion coefficients do not discriminate between benign and metastatic nodes .