Relapsing visceral leishmaniasis in a HIV-1 infected patient with advanced disease

Leishmaniasis, an intracellular protozoal infection in which tissue macrophages are targeted, is transmitted by female sandfly bite and occurs in 98 countries. Visceral leishmaniasis (VL) is the clinical form of leishmaniasis most frequently associated with HIV, especially in Europe. Both diseases h...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 2013-03, Vol.68 (2), p.124-127
Main Authors: Standaert, D, Laurent, F, Jonckheere, S, Scheiff, J M, Vandercam, B, Yombi, J C
Format: Article
Language:English
Subjects:
Amphotericin B - therapeutic use
Antiprotozoal Agents - therapeutic use
Diagnosis, Differential
Drug dosages
Drug resistance
Epidemiology
Family medical history
Fever
HIV
HIV Infections - complications
HIV-1
Human immunodeficiency virus
Humans
Infections
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - diagnosis
Leishmaniasis, Visceral - drug therapy
Male
Middle Aged
Mortality
Parasites
Parasitic diseases
Patients
Recurrence
Substance abuse treatment
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Summary:Leishmaniasis, an intracellular protozoal infection in which tissue macrophages are targeted, is transmitted by female sandfly bite and occurs in 98 countries. Visceral leishmaniasis (VL) is the clinical form of leishmaniasis most frequently associated with HIV, especially in Europe. Both diseases have a synergistic detrimental effect on the cellular immune response. Treatment of VL in patients with underlying HIV-infection is associated with lower cure rates, higher rates of drug toxicity, higher relapse rates and greater mortality than treatment of VL in immunocompetent patients. We report the case of a HIV-1 infected patient with advanced disease who presented VL with multiple relapses. This case highlights the difficulties of treating VL in patients with HIV co-infection.
ISSN:1784-3286
2295-3337
DOI:10.2143/ACB.3207