Developing heatable microfluidic chip to generate gelatin emulsions and microcapsules

The heatable microfluidic chip developed herein successfully integrates a microheater and flow-focusing device to generate uniform-sized gelatin emulsions under various flow rate ratios (sample phase/oil phase, Q s / Q o ) and driven voltages. The gelatin emulsions can be applied to encapsulate vita...

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Bibliographic Details
Published in:Microfluidics and nanofluidics 2013-12, Vol.15 (6), p.775-784
Main Authors: Yeh, Chia-Hsien, Chen, Ke-Rong, Lin, Yu-Cheng
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biological and medical sciences
Biomedical Engineering and Bioengineering
Coefficient of variation
Emulsions
Engineering
Engineering Fluid Dynamics
Flow rates
General pharmacology
Medical sciences
Nanotechnology and Microengineering
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Research Paper
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Summary:The heatable microfluidic chip developed herein successfully integrates a microheater and flow-focusing device to generate uniform-sized gelatin emulsions under various flow rate ratios (sample phase/oil phase, Q s / Q o ) and driven voltages. The gelatin emulsions can be applied to encapsulate vitamin C for drug release. Our goal is to create the thermal conditions for thermo-sensitive hydrogel materials in the microfluidic chip and generate continuous and uniform emulsions under any external environment. The gelatin emulsion sizes have a coefficient of variation of
ISSN:1613-4982
1613-4990
DOI:10.1007/s10404-013-1193-x