Structure–Activity Relationship of Insulinomimetic Activity of Zinc(II) Complexes with Pyridine-2-sulfonic Acid Derivatives

We prepared zinc(II) complexes with a series of mono-methyl-substituted pyridine-2-sulfonic acid derivatives to clarify the relationship between the structure and insulinomimetic activity. Towards in vitro insulinomimetic activity, bis(3-methylpyridine-2-sulfonato)zinc(II) gave the best result among...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2007-03, Vol.80 (3), p.530-532
Main Authors: Yoshikawa, Yutaka, Morishita, Mika, Nishide, Midori, Yoshikawa, Eriko U, Kinoshita, Isamu, Okada, Keiji, Kajiwara, Naemi M, Sakurai, Hiromu, Kojima, Yoshitane
Format: Article
Language:English
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Summary:We prepared zinc(II) complexes with a series of mono-methyl-substituted pyridine-2-sulfonic acid derivatives to clarify the relationship between the structure and insulinomimetic activity. Towards in vitro insulinomimetic activity, bis(3-methylpyridine-2-sulfonato)zinc(II) gave the best result among the zinc(II) complexes with methylpyridine-2-sulfonates.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.80.530