Epigenetics: Novel Mechanism of Pulmonary Hypertension

Introduction Epigenetics refers to changes in phenotype and gene expression that occur without alterations in DNA sequence. MicroRNAs are relatively recently discovered negative regulators of gene expression and act at the posttranscriptional level. Methods This review summarizes epigenetic mechanis...

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Bibliographic Details
Published in:Lung 2013-12, Vol.191 (6), p.601-610
Main Authors: Huang, Jing-bin, Liang, Jian, Zhao, Xiao-fang, Wu, Wen-sen, Zhang, Fu
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - therapeutic use
Base sequence
Blood Pressure - drug effects
Blood Pressure - genetics
Care and treatment
Chromatin Assembly and Disassembly
Complications and side effects
CpG Islands
Development and progression
Diagnosis
DNA Methylation
Epigenesis, Genetic - drug effects
Epigenetic inheritance
Epigenetics
Gene Expression Regulation
Genetic aspects
Genetic Predisposition to Disease
Genetic Therapy
Genomics
Histones - metabolism
Humans
Hypertension, Pulmonary - genetics
Hypertension, Pulmonary - metabolism
Hypertension, Pulmonary - physiopathology
Hypertension, Pulmonary - therapy
Medicine
Medicine & Public Health
Methylation
MicroRNA
MicroRNAs
MicroRNAs - metabolism
MicroRNAs - therapeutic use
Patient outcomes
Phenotype
Phenotypes
Physiological aspects
Pneumology/Respiratory System
Prognosis
Pulmonary hypertension
Risk factors
Systems Biology
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Summary:Introduction Epigenetics refers to changes in phenotype and gene expression that occur without alterations in DNA sequence. MicroRNAs are relatively recently discovered negative regulators of gene expression and act at the posttranscriptional level. Methods This review summarizes epigenetic mechanisms of pulmonary hypertension, focusing on microRNAs related to pulmonary hypertension. Results There are three major mechanisms of epigenetic regulation, including methylation of CpG islands, modification of histone proteins, and microRNAs. There may be an epigenetic component to pulmonary hypertension. These epigenetic abnormalities can be reversed therapeutically. Conclusions By better integrating network biology with evolving technologies in cell culture and in vivo experimentation, we will better understand epigenetic mechanisms of pulmonary hypertension and identify more diagnostic and therapeutic targets in pulmonary hypertension.
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-013-9505-1