Cr3+-Mediated Addition of Arylzincs to Aldehydes

Addition of arylzincs to aldehydes was achieved by making use of the novel transmetallation of arylzincs into Cr3+ compounds. Various α-substituted benzyl alcohols or 3-substituted 1(3H)-isobenzofuranones, containing reactive functional groups, were synthesized in good yields. Me3SiCl exerted benefi...

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Bibliographic Details
Published in:Chemistry letters 1996-12, Vol.25 (12), p.1069-1070
Main Authors: Ogawa, Yoshihiro, Mori, Mitsuo, Saiga, Akihiro, Takagi, Kentaro
Format: Article
Language:English
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Summary:Addition of arylzincs to aldehydes was achieved by making use of the novel transmetallation of arylzincs into Cr3+ compounds. Various α-substituted benzyl alcohols or 3-substituted 1(3H)-isobenzofuranones, containing reactive functional groups, were synthesized in good yields. Me3SiCl exerted beneficial effects on the reaction.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1996.1069