Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic Acid through Lipase-Catalyzed Asymmetric Acetylation

(+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.

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Bibliographic Details
Published in:Chemistry letters 1999-05, Vol.28 (5), p.405-406
Main Authors: Kirihara, Masayuki, Takuwa, Tomofumi, Kawasaki, Masashi, Kakuda, Hiroko, Hirokami, Shun-ichi, Takahata, Hiroki
Format: Article
Language:English
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Description
Summary:(+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1999.405