Syntheses and Biological Activities of Dendrimeric Mastoparans

Dendritic formation of mastoparan molecule by a carboxyl-terminal linkage to a lysine branch increased the original mastoparan activity for hemolysis and catecholamine release from adrenal chromaffin cells. The most potent dendrimer in hemolytic activity, approximately 8000 times as active as mastop...

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Bibliographic Details
Published in:Chemistry letters 1999-03, Vol.28 (3), p.193-194
Main Authors: Kurita, Takashi, Kosemura, Yoshiko, Kumakura, Konosuke, Kasai, Hisataka, Ito, Hisashi
Format: Article
Language:English
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Summary:Dendritic formation of mastoparan molecule by a carboxyl-terminal linkage to a lysine branch increased the original mastoparan activity for hemolysis and catecholamine release from adrenal chromaffin cells. The most potent dendrimer in hemolytic activity, approximately 8000 times as active as mastoparan, was octameric mastoparan.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.1999.193