Paecilospirone, a Unique Spiro[chroman-2,1′(3′H)-isobenzofuran] Derivative Isolated from Tropical Marine Fungus Paecilomyces sp

A spiroacetal compound named paecilospirone was isolated from a marine fungus Paecilomyces sp. Collected at Yap Island. Paecilospirone was found by the screening assay for detecting inhibitors of microtubule assembly using conidia of Pyricularia oryzae. The structure was assigned based on the spectr...

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Bibliographic Details
Published in:Chemistry letters 2000-04, Vol.29 (4), p.308-309
Main Authors: Namikoshi, Michio, Kobayashi, Hisayoshi, Yoshimoto, Takeshi, Meguro, Shiori
Format: Article
Language:English
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Summary:A spiroacetal compound named paecilospirone was isolated from a marine fungus Paecilomyces sp. Collected at Yap Island. Paecilospirone was found by the screening assay for detecting inhibitors of microtubule assembly using conidia of Pyricularia oryzae. The structure was assigned based on the spectroscopic data. This is the first report of the isolation and characterization of spiro[chroman-2,1′(3′H)-isobenzofuran] derivative as a natural product.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2000.308