Useful Synthesis of the Main Dehydrohexapeptide Segment of a Macrocyclic Antibiotic, Berninamycin B

The useful synthesis of tetradehydrohexapeptide segment 2, which is the main skeleton of a macrocyclic antibiotic, berninamycin B, was first achieved. The skeleton 2 is constructed, in turn, of 2-[(Z)-1-amino-1-propenyl]-5-methyl-oxazole-4-carboxylic acid, α-dehydroalanine (ΔAla), L-Val, 2-[1-amino-...

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Bibliographic Details
Published in:Chemistry letters 2001-02, Vol.30 (2), p.102-103
Main Authors: Yamada, Takahiro, Okumura, Kazuo, Yonezawa, Yasuchika, Shin, Chung-gi
Format: Article
Language:English
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Summary:The useful synthesis of tetradehydrohexapeptide segment 2, which is the main skeleton of a macrocyclic antibiotic, berninamycin B, was first achieved. The skeleton 2 is constructed, in turn, of 2-[(Z)-1-amino-1-propenyl]-5-methyl-oxazole-4-carboxylic acid, α-dehydroalanine (ΔAla), L-Val, 2-[1-amino-1-ethenyl]-5-methyloxazole-4-carboxylic acid residues, besides L-Thr and ΔAla at the N- and C-termini, respectively.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2001.102