Enhanced Effect of Mesoporous Silica on Base-Catalyzed Aldol Reaction

Aldol reaction of 4-nitrobenzaldehyde with acetone gives 4-(4-nitrophenyl)-4-hydroxy-2-butanone in high yield in the presence of both secondary amine and mesoporous silica, whereas the yield is low in the absence of the mesoporous silica.

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Bibliographic Details
Published in:Chemistry letters 2003-03, Vol.32 (3), p.234-235
Main Authors: Kubota, Yoshihiro, Goto, Kunio, Miyata, Shintaro, Goto, Yasutomo, Fukushima, Yoshiaki, Sugi, Yoshihiro
Format: Article
Language:English
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Description
Summary:Aldol reaction of 4-nitrobenzaldehyde with acetone gives 4-(4-nitrophenyl)-4-hydroxy-2-butanone in high yield in the presence of both secondary amine and mesoporous silica, whereas the yield is low in the absence of the mesoporous silica.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2003.234