Synthesis and Stereochemical Assignment of Angucycline Antibiotic, PD-116740

The first total synthesis and absolute structure assignment of PD-116740 (2) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde.

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Published in:Chemistry letters 2008-04, Vol.37 (4), p.470-471
Main Authors: Mori, Keiji, Tanaka, Yuuya, Ohmori, Ken, Suzuki, Keisuke
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Language:English
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creator Mori, Keiji
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Suzuki, Keisuke
description The first total synthesis and absolute structure assignment of PD-116740 (2) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde.
doi_str_mv 10.1246/cl.2008.470
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title Synthesis and Stereochemical Assignment of Angucycline Antibiotic, PD-116740
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