Highly Efficient Method for the Synthesis of Carboxamides from Carboxylic Acids and Amines Using Pyridine-3-sulfonyl Chloride (3-PSC)

The use of pyridine-3-sulfonyl chloride (3-PSC) in dehydrating condensation was investigated. This novel reagent was successfully employed as a mild dehydrating reagent for preparing various carboxamides in good to excellent yields from the corresponding carboxylic acids and amines.

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Bibliographic Details
Published in:Chemistry letters 2008-05, Vol.37 (5), p.506-507
Main Authors: Funasaka, Setsuo, Kato, Koji, Mukaiyama, Teruaki
Format: Article
Language:English
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Description
Summary:The use of pyridine-3-sulfonyl chloride (3-PSC) in dehydrating condensation was investigated. This novel reagent was successfully employed as a mild dehydrating reagent for preparing various carboxamides in good to excellent yields from the corresponding carboxylic acids and amines.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2008.506