Folate Receptor Mediated Targeted Delivery of Porphyrin Photosensitizer

A folate–porphyrin conjugate 1 has been synthesized and characterized. The cellular uptake of conjugate 1 by Hela cells was about 35 times higher than that of precursor porphyrin 3 after 24 h of incubation and can be inhibited competitively by free folic acid. Moreover, conjugate 1 exhibited much lo...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry letters 2009-12, Vol.38 (12), p.1158-1159
Main Authors: Li, Donghong, Wang, Dong, Diao, Junlin, Liu, Jianchang
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A folate–porphyrin conjugate 1 has been synthesized and characterized. The cellular uptake of conjugate 1 by Hela cells was about 35 times higher than that of precursor porphyrin 3 after 24 h of incubation and can be inhibited competitively by free folic acid. Moreover, conjugate 1 exhibited much lower dark cytotoxicity against Hela cells in vitro but significant photocytotoxicity with 86.4% cell growth inhibition ratio after irradiation.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2009.1158