Folate Receptor Mediated Targeted Delivery of Porphyrin Photosensitizer

A folate–porphyrin conjugate 1 has been synthesized and characterized. The cellular uptake of conjugate 1 by Hela cells was about 35 times higher than that of precursor porphyrin 3 after 24 h of incubation and can be inhibited competitively by free folic acid. Moreover, conjugate 1 exhibited much lo...

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Published in:Chemistry letters 2009-12, Vol.38 (12), p.1158-1159
Main Authors: Li, Donghong, Wang, Dong, Diao, Junlin, Liu, Jianchang
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description A folate–porphyrin conjugate 1 has been synthesized and characterized. The cellular uptake of conjugate 1 by Hela cells was about 35 times higher than that of precursor porphyrin 3 after 24 h of incubation and can be inhibited competitively by free folic acid. Moreover, conjugate 1 exhibited much lower dark cytotoxicity against Hela cells in vitro but significant photocytotoxicity with 86.4% cell growth inhibition ratio after irradiation.
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title Folate Receptor Mediated Targeted Delivery of Porphyrin Photosensitizer
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