Screening Anti-influenza Agents that Target Avian Influenza Polymerase Protein PAC from Plant Extracts Based on NMR Methods

The highly pathogenic avian influenza A virus poses a global threat to human health. Avian influenza RNA polymerase protein PAC was used in the screening of two herbal plant extracts for anti-influenza agents. As a result, chlorogenic acid was identified to be PAC ligand and was discovered to inhibi...

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Bibliographic Details
Published in:Chemistry letters 2011-08, Vol.40 (8), p.801-803
Main Authors: Li, Lin, Chang, Sheng-Hai, Xiang, Jun-Feng, Li, Qian, Liang, Huan-Huan, Li, Jian, Bao, Hong-Juan, Tang, Ya-Lin, Liu, Ying-Fang
Format: Article
Language:English
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Summary:The highly pathogenic avian influenza A virus poses a global threat to human health. Avian influenza RNA polymerase protein PAC was used in the screening of two herbal plant extracts for anti-influenza agents. As a result, chlorogenic acid was identified to be PAC ligand and was discovered to inhibit polymerase activity. Hence, this work revealed a potential anti-influenza lead compound and provided an important step in the discovery of new anti-influenza drugs.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2011.801