Disability is the major negative predictor for achievement of Boolean-based remission in patients with rheumatoid arthritis treated with tocilizumab

Abstract Objective: To analyze the efficacy of tocilizumab (TCZ) and the factors that influence achievement of Boolean-based remission in patients with rheumatoid arthritis (RA) treated with TCZ in daily clinical practice. Methods: The efficacy of TCZ at 24 weeks after initiation of TCZ in 80 patien...

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Bibliographic Details
Published in:Modern rheumatology 2013-11, Vol.23 (6), p.1205-1210
Main Authors: Hoshi, Daisuke, Nakajima, Ayako, Shidara, Kumi, Seto, Yohei, Tanaka, Eiichi, Taniguchi, Atsuo, Momohara, Shigeki, Yamanaka, Hisashi
Format: Article
Language:English
Subjects:
Boolean criteria
Comparative analysis
Disability
Medical treatment
Regression analysis
Remission
Rheumatoid arthritis
Tocilizumab
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Summary:Abstract Objective: To analyze the efficacy of tocilizumab (TCZ) and the factors that influence achievement of Boolean-based remission in patients with rheumatoid arthritis (RA) treated with TCZ in daily clinical practice. Methods: The efficacy of TCZ at 24 weeks after initiation of TCZ in 80 patients with RA was analyzed by comparing achievement of “DAS28 remission” with that of “Boolean-based remission”. The predictive factors that influence achievement of Boolean-based remission were determined using multiple logistic regression analysis using a step-wise method. Results: DAS28 remission and Boolean-based remission were achieved in 50.0 and 12.5 % of patients, respectively. Significant differences in achieving Boolean-based remission were observed when patients were stratified by disease duration in tertiles (p 
ISSN:1439-7595
1439-7609
DOI:10.3109/s10165-012-0825-4