Protective role of CYP2E1 inhibitor diallyl disulfide (DADS) on alcohol induced malondialdehyde-deoxyguanosine (M1dG) adduct formation

MDA is genotoxic and can lead to the formation of various DNA adducts such as malondialdehyde deoxyguanosine (M1dG) adducts which have been implicated in alcohol-related cancers and cardiovascular disease. Since the CYP2E1 pathway of alcohol metabolism is involved in the formation of MDA, and our pr...

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Bibliographic Details
Published in:Alcohol (Fayetteville, N.Y.) N.Y.), 2013-11, Vol.47 (7), p.574-574
Main Authors: Sapkota, M, Hottor, T.K, DeVasure, J.M, Wyatt, T.A, McCaskill, M.L
Format: Article
Language:English
Subjects:
Alcohol
Ethanol
Lungs
Psychiatry
Smoking
Tobacco smoke
Online Access:Get full text
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Summary:MDA is genotoxic and can lead to the formation of various DNA adducts such as malondialdehyde deoxyguanosine (M1dG) adducts which have been implicated in alcohol-related cancers and cardiovascular disease. Since the CYP2E1 pathway of alcohol metabolism is involved in the formation of MDA, and our previous studies have shown that alcohol and cigarette smoke can lead to MDA formation, we hypothesized that CYP2E1 would regulate MDA production, M1dG adduct formation, and single strand DNA damage in alcohol- and cigarette smoke-exposed lung cells and tissue.
ISSN:0741-8329
1873-6823
DOI:10.1016/j.alcohol.2013.09.031