Confluence of [alpha]-Synuclein, Tau, and [Beta]-Amyloid Pathologies in Dementia With Lewy Bodies

Dementia with Lewy bodies (DLB) is pathologically characterized by α-synuclein aggregates in the brain. Most patients with DLB also show cerebral ALzheimer disease-type pathology. It is unclear whether this overlap is coincidental or driven by specific regional or cellular interactions. The aims of...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2013-12, Vol.72 (12), p.1203
Main Authors: Colom-Cadena, Martí, Gelpi, Ellen, Charif, Sara, Belbin, Olivia, Blesa, Rafael, Martí, Maria J, Clarimón, Jordi, Lleó, Alberto
Format: Article
Language:English
Subjects:
Brain research
Cloning
Disease
Haplotypes
Microscopy
Neural networks
Neuropathology
Pathology
Proteins
Studies
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Summary:Dementia with Lewy bodies (DLB) is pathologically characterized by α-synuclein aggregates in the brain. Most patients with DLB also show cerebral ALzheimer disease-type pathology. It is unclear whether this overlap is coincidental or driven by specific regional or cellular interactions. The aims of this study were to investigate the regional convergence of α-synuclein, tau, and β-amyloid and to identify patterns of cellular co-occurrence of tau and α-synuclein in DLB. The study group consisted of 22 patients who met clinical and neuropathologic criteria for DLB. Protein aggregates were assessed semiquantitatively in 17 brain areas. APOE and MART genotypes were determined. Cellular co-occurrence of tau and α-synuclein was evaluated by double immunofluorescence. The authors have found that, total β-amyloid pathology scores correlated positively with total α-synuclein pathology scores. The factors that correlated best with the amount of α-synuclein pathology were the severity of β-amyloid pathology and presence of the MAPT H1 haplotype.
ISSN:0022-3069
1554-6578