Developmental effects of boric acid in rats related to maternal blood boron concentrations

Timed-mated Sprague-Dawley rats (60/group) were exposed to boric acid (BA) from gestational days (gd) 0 to 20. BA added to the diet (0, 0.025, 0.050, 0.075, 0.1, or 0.2%) yielded boron (B) intakes of 10-fold increase in maternal blood B (2.82 +/- 0.987 vs. 0.229 +/- 0.143 microg B/g for controls). M...

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Bibliographic Details
Published in:Biological trace element research 1998, Vol.66 (1/3), p.359-372
Main Authors: Price, C.J, Strong, P.L, Murray, F.J, Goldberg, M.M
Format: Article
Language:English
Subjects:
Animals
Blood
Body weight
Body Weight - drug effects
boric acid
Boric Acids - blood
Boric Acids - toxicity
Boron
concentration
Dose-Response Relationship, Drug
embryogenesis
Embryonic and Fetal Development - drug effects
Female
Fetal Viability - drug effects
Fetuses
High temperature
Male
maternal effect
Musculoskeletal Abnormalities - chemically induced
No-Observed-Adverse-Effect Level
Pregnancy
Pregnancy, Animal - blood
Rats
Rats, Sprague-Dawley
Ribs - abnormalities
Rodents
Spectrometry
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Summary:Timed-mated Sprague-Dawley rats (60/group) were exposed to boric acid (BA) from gestational days (gd) 0 to 20. BA added to the diet (0, 0.025, 0.050, 0.075, 0.1, or 0.2%) yielded boron (B) intakes of 10-fold increase in maternal blood B (2.82 +/- 0.987 vs. 0.229 +/- 0.143 microg B/g for controls). Maternal blood B concentrations were: 1. Significantly elevated in all BA-exposed groups. 2. Positively correlated with maternal BA intake. 3. Inversely correlated with fetal body weight at doses above the NOAEL.
ISSN:0163-4984
1559-0720
DOI:10.1007/BF02783148