SOME TOXIC PROPERTIES OF A CARCINOGENIC PYRROLIZIDINE ALKALOID, PETASITENINE

Some toxic properties of petasitenine, a hepatocarcinogenic pyrrolizidine alkaloid, were confirmed in 3 parts of studies. Electron microscopic observation of rat liver on the stage of acute toxicity following administration of a toxic dose of petasitenine disclosed the distinctive changes i.e., nucl...

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Bibliographic Details
Published in:Journal of toxicological sciences 1984/05/25, Vol.9(2), pp.143-149
Main Authors: MORI, Hideki, KAWAI, Kiyoshi, OHBAYASHI, Futoshi, BUNAI, Yasuo, YAMADA, Kiyoyuki, HIRONO, Iwao
Format: Article
Language:English
Subjects:
Animals
Azabicyclo Compounds
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - toxicity
Cell Cycle - drug effects
Cell Nucleolus - ultrastructure
Cell Nucleus - ultrastructure
Chemical agents
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - pathology
Endoplasmic Reticulum - ultrastructure
In Vitro Techniques
Lung Neoplasms - ultrastructure
Male
Medical sciences
Mitochondria - ultrastructure
Mitochondria, Liver - metabolism
Oxidative Phosphorylation - drug effects
Pyrrolizidine Alkaloids - toxicity
Rats
Rats, Inbred ACI
toxicity
Tumors
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Summary:Some toxic properties of petasitenine, a hepatocarcinogenic pyrrolizidine alkaloid, were confirmed in 3 parts of studies. Electron microscopic observation of rat liver on the stage of acute toxicity following administration of a toxic dose of petasitenine disclosed the distinctive changes i.e., nucleolar segregation, degradation of endoplasmic reticulum such as formation of concentric whorls in the liver cells. Biochemical test for the mitochondrial function in the isolated mitochondria from rat liver cells revealed on inhibitory effects of petasitenine in the respiratory system, indicating that minor changes of mitochondria on the pyrrolizidine alkaloid may be induced by some other indirect factor. Investigation for the effect of petasitenine on the cell cycle of the cultured cell line from the human carcinoma showed some inhibitory effects in the appearance of cells in S-phase or M-phase, suggesting a possibility that toxicity of petasitenine will be developed in the tissues other than the liver or in the species apart from rodents.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.9.143