SPONTANEOUS TUMORS IN F-344/Jcl RATS

The age-related incidence of spontaneously occuring neoplastic and non-neoplastic lesions in untreated F-344/Jcl rats, used as controls in carcinogenicity testing, were studied from the histological examination of tissues from 469 males and 354 females. The incidence of spontaneous tumors was 83.2%...

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Bibliographic Details
Published in:Journal of toxicological sciences 1989/08/25, Vol.14(3), pp.181-195
Main Authors: TAKAKI, Yuki, KITAMURA, Sigehiro, UEKUSA, Toshimasa, HONMA, Sakae, AZE, Yoshiya, WAKABAYASHI, Kazuo, KUWABARA, Noriyuki, FUKUDA, Yoshiro
Format: Article
Language:English
Subjects:
Age Factors
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Bone Neoplasms - veterinary
Digestive System Neoplasms - veterinary
Endocrine System Diseases - veterinary
F-344/Jcl rats
Female
Genital Neoplasms, Female - veterinary
Genital Neoplasms, Male - veterinary
Leukemia - veterinary
Male
Medical sciences
Muscular Diseases - veterinary
Neoplasms - epidemiology
Neoplasms - veterinary
Rats
Rats, Inbred F344
Rats, Inbred Strains
Respiratory Tract Neoplasms - veterinary
Rodent Diseases - epidemiology
Sex Factors
Skin Neoplasms - veterinary
Spontaneous animal tumors
Tumors
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Summary:The age-related incidence of spontaneously occuring neoplastic and non-neoplastic lesions in untreated F-344/Jcl rats, used as controls in carcinogenicity testing, were studied from the histological examination of tissues from 469 males and 354 females. The incidence of spontaneous tumors was 83.2% in the males and 71.2% in the females. The most common neoplasms were leukemia (males : 24.3%, females : 24.0%), pituitary adenoma (males : 16.0%, females : 45.2%), pheochromocytoma (males : 14.7% females : 7.3%, testicular interstitial cell tumor (males : 79.1%), and uterine endometrial stromal polyp(females : 16.4%). The incidence of other tumors of almost all the organs and/or tissues was low. Non-neoplastic lesions generally increased with advancing age of the animals.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.14.181