Oral Fluid Cannabinoids in Chronic Cannabis Smokers during Oral [Delta]^sup 9^-Tetrahydrocannabinol Therapy and Smoked Cannabis Challenge

Oral Δ^sup 9^-tetrahydrocannabinol (THC) is effective for attenuating cannabis withdrawal and may benefit treatment of cannabis use disorders. Oral fluid (OF) cannabinoid testing, increasing in forensic and workplace settings, could be valuable for monitoring during cannabis treatment. Eleven cannab...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2013-12, Vol.59 (12), p.1770
Main Authors: Lee, Dayong, Vandrey, Ryan, Mendu, Damodara R, Anizan, Sebastien, Milman, Garry, Murray, Jeannie A, Barnes, Allan J, Huestis, Marilyn A
Format: Article
Language:English
Subjects:
Addictive behaviors
Behavior
Drug dosages
Heart rate
Marijuana
Mental disorders
Smoking
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Summary:Oral Δ^sup 9^-tetrahydrocannabinol (THC) is effective for attenuating cannabis withdrawal and may benefit treatment of cannabis use disorders. Oral fluid (OF) cannabinoid testing, increasing in forensic and workplace settings, could be valuable for monitoring during cannabis treatment. Eleven cannabis smokers resided on a closed research unit for 51 days and received daily 0, 30, 60, and 120 mg of oral THC in divided doses for 5 days. There was a 5-puff smoked cannabis challenge on the fifth day. Each medication session was separated by 9 days of ad libitum cannabis smoking. OF was collected the evening before and throughout oral THC sessions and analyzed by 2-dimensional GC-MS for THC, cannabidiol (CBD), cannabinol (CBN), 11-hydroxy-THC (11-OH-THC), and 11 -nor-9-carboxy-THC (THCCOOH). During all oral THC administrations, THC OF concentrations decreased to
ISSN:0009-9147
1530-8561