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EFFECTS OF CISPLATIN ON ERYTHROPOIETIN PRODUCTION IN RATS
The effects of cisplatin on erythropoietin (EPO) production were investigated in comparison with the effects of phenylhydrazine in rats. Cisplatin (4.5 mg/kg i.p. bolus) decreased red blood cell count (RBC), hematocrit (Hct) and hemoglobin concentration (Hgb) for 14 days after dosing. These decrease...
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| Published in: | Journal of toxicological sciences 1996/08/25, Vol.21(3), pp.157-165 |
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| container_end_page | 165 |
| container_issue | 3 |
| container_start_page | 157 |
| container_title | Journal of toxicological sciences |
| container_volume | 21 |
| creator | UNAMI, Akira NISHINA, Noriko TERAI, Takao SATO, Susumu TAMURA, Takayuki NODA, Kohsei MINE, Yasuhiro |
| description | The effects of cisplatin on erythropoietin (EPO) production were investigated in comparison with the effects of phenylhydrazine in rats. Cisplatin (4.5 mg/kg i.p. bolus) decreased red blood cell count (RBC), hematocrit (Hct) and hemoglobin concentration (Hgb) for 14 days after dosing. These decreases were accompanied with increases of blood urea nitrogen (BUN) and serum creatinine (s-CRE). Both serum EPO concentration and kidney EPO mRNA content were significantly decreased in cisplatin-treated rats. On the other hand, phenylhydrazine (10 mg/kg p.o. once a day for 8 days) decreased RBC, Hct and Hgb, and increased serum EPO concentration and kidney EPO mRNA content. Phenylhydrazine had little effect on BUN or s-CRE. These results suggest that a suppression of EPO production is involved in the pathophysiology of cisplatin-induced renal anemia and that measurement of serum EPO concentration and kidney EPO mRNA content is available for distinguishing renal anemia from hemolytic anemia. |
| doi_str_mv | 10.2131/jts.21.3_157 |
| format | article |
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Cisplatin (4.5 mg/kg i.p. bolus) decreased red blood cell count (RBC), hematocrit (Hct) and hemoglobin concentration (Hgb) for 14 days after dosing. These decreases were accompanied with increases of blood urea nitrogen (BUN) and serum creatinine (s-CRE). Both serum EPO concentration and kidney EPO mRNA content were significantly decreased in cisplatin-treated rats. On the other hand, phenylhydrazine (10 mg/kg p.o. once a day for 8 days) decreased RBC, Hct and Hgb, and increased serum EPO concentration and kidney EPO mRNA content. Phenylhydrazine had little effect on BUN or s-CRE. These results suggest that a suppression of EPO production is involved in the pathophysiology of cisplatin-induced renal anemia and that measurement of serum EPO concentration and kidney EPO mRNA content is available for distinguishing renal anemia from hemolytic anemia.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.21.3_157</identifier><identifier>PMID: 8887884</identifier><identifier>CODEN: JTSCDR</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Toxicology</publisher><subject>Anemia - blood ; Anemia - chemically induced ; Anemia - physiopathology ; Animals ; Antineoplastic Agents - toxicity ; Biological and medical sciences ; Blood Urea Nitrogen ; Cisplatin ; Cisplatin - toxicity ; Creatinine - blood ; Drug toxicity and drugs side effects treatment ; Erythrocyte Count - drug effects ; Erythropoietin - biosynthesis ; Erythropoietin - blood ; Hematocrit ; Hemoglobins - drug effects ; Immunoenzyme Techniques ; Kidney - drug effects ; Kidney - metabolism ; Kidney Diseases - blood ; Kidney Diseases - chemically induced ; Kidney Diseases - physiopathology ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Phenylhydrazines ; Polymerase Chain Reaction ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Toxicity: blood ; Transcription, Genetic</subject><ispartof>The Journal of Toxicological Sciences, 1996/08/25, Vol.21(3), pp.157-165</ispartof><rights>The Japanese Society of Toxicology Headquarters</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1996</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2498233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8887884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>UNAMI, Akira</creatorcontrib><creatorcontrib>NISHINA, Noriko</creatorcontrib><creatorcontrib>TERAI, Takao</creatorcontrib><creatorcontrib>SATO, Susumu</creatorcontrib><creatorcontrib>TAMURA, Takayuki</creatorcontrib><creatorcontrib>NODA, Kohsei</creatorcontrib><creatorcontrib>MINE, Yasuhiro</creatorcontrib><title>EFFECTS OF CISPLATIN ON ERYTHROPOIETIN PRODUCTION IN RATS</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>The effects of cisplatin on erythropoietin (EPO) production were investigated in comparison with the effects of phenylhydrazine in rats. Cisplatin (4.5 mg/kg i.p. bolus) decreased red blood cell count (RBC), hematocrit (Hct) and hemoglobin concentration (Hgb) for 14 days after dosing. These decreases were accompanied with increases of blood urea nitrogen (BUN) and serum creatinine (s-CRE). Both serum EPO concentration and kidney EPO mRNA content were significantly decreased in cisplatin-treated rats. On the other hand, phenylhydrazine (10 mg/kg p.o. once a day for 8 days) decreased RBC, Hct and Hgb, and increased serum EPO concentration and kidney EPO mRNA content. Phenylhydrazine had little effect on BUN or s-CRE. These results suggest that a suppression of EPO production is involved in the pathophysiology of cisplatin-induced renal anemia and that measurement of serum EPO concentration and kidney EPO mRNA content is available for distinguishing renal anemia from hemolytic anemia.</description><subject>Anemia - blood</subject><subject>Anemia - chemically induced</subject><subject>Anemia - physiopathology</subject><subject>Animals</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Cisplatin</subject><subject>Cisplatin - toxicity</subject><subject>Creatinine - blood</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Erythrocyte Count - drug effects</subject><subject>Erythropoietin - biosynthesis</subject><subject>Erythropoietin - blood</subject><subject>Hematocrit</subject><subject>Hemoglobins - drug effects</subject><subject>Immunoenzyme Techniques</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney Diseases - blood</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenylhydrazines</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>Toxicity: blood</subject><subject>Transcription, Genetic</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNo9kD1PwzAQhi0EKqWwsSJFgjXFzuXjPFYhoZGqpkrTgcmyEwca9QPidODfY9Soi8_28-hO7xHyyOjUY8Be297YyxQEC6IrMmaI1AWO_JqMKSC6DAJ6S-6MaSn1Ihr4IzJCxAjRHxOepGkSl2snT504W68WszJbOvnSSYqPcl7kqzxL_n9WRf62icvMEvsqZuX6ntw0cmf0w1AnZJMmZTx3F_l7Fs8WbusB9q5SWgVAVc0iaCBqfAQlWVWpsEZsVM39QAeSh0HQ-JSCDiuGkS0e0FoqZDAhz-e-393x56RNL9rjqTvYkYL5oc0BnHJrPQ3WSe11Lb677V52v2IIavnLwKWp5K7p5KHamovm-Rw9AKvFZ601vfzUFy67flvttLC7ZjwKhccEnA-79AutvmQn9AH-AMqacuM</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>UNAMI, Akira</creator><creator>NISHINA, Noriko</creator><creator>TERAI, Takao</creator><creator>SATO, Susumu</creator><creator>TAMURA, Takayuki</creator><creator>NODA, Kohsei</creator><creator>MINE, Yasuhiro</creator><general>The Japanese Society of Toxicology</general><general>Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>199608</creationdate><title>EFFECTS OF CISPLATIN ON ERYTHROPOIETIN PRODUCTION IN RATS</title><author>UNAMI, Akira ; NISHINA, Noriko ; TERAI, Takao ; SATO, Susumu ; TAMURA, Takayuki ; NODA, Kohsei ; MINE, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j238t-bbeb530bd173f37f483ba1ccb6d88fbd945e5a9655f4003e6c1873e6230dab813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Anemia - blood</topic><topic>Anemia - chemically induced</topic><topic>Anemia - physiopathology</topic><topic>Animals</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Blood Urea Nitrogen</topic><topic>Cisplatin</topic><topic>Cisplatin - toxicity</topic><topic>Creatinine - blood</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Erythrocyte Count - drug effects</topic><topic>Erythropoietin - biosynthesis</topic><topic>Erythropoietin - blood</topic><topic>Hematocrit</topic><topic>Hemoglobins - drug effects</topic><topic>Immunoenzyme Techniques</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney Diseases - blood</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenylhydrazines</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - metabolism</topic><topic>Toxicity: blood</topic><topic>Transcription, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>UNAMI, Akira</creatorcontrib><creatorcontrib>NISHINA, Noriko</creatorcontrib><creatorcontrib>TERAI, Takao</creatorcontrib><creatorcontrib>SATO, Susumu</creatorcontrib><creatorcontrib>TAMURA, Takayuki</creatorcontrib><creatorcontrib>NODA, Kohsei</creatorcontrib><creatorcontrib>MINE, Yasuhiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UNAMI, Akira</au><au>NISHINA, Noriko</au><au>TERAI, Takao</au><au>SATO, Susumu</au><au>TAMURA, Takayuki</au><au>NODA, Kohsei</au><au>MINE, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF CISPLATIN ON ERYTHROPOIETIN PRODUCTION IN RATS</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>1996-08</date><risdate>1996</risdate><volume>21</volume><issue>3</issue><spage>157</spage><epage>165</epage><pages>157-165</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><coden>JTSCDR</coden><abstract>The effects of cisplatin on erythropoietin (EPO) production were investigated in comparison with the effects of phenylhydrazine in rats. Cisplatin (4.5 mg/kg i.p. bolus) decreased red blood cell count (RBC), hematocrit (Hct) and hemoglobin concentration (Hgb) for 14 days after dosing. These decreases were accompanied with increases of blood urea nitrogen (BUN) and serum creatinine (s-CRE). Both serum EPO concentration and kidney EPO mRNA content were significantly decreased in cisplatin-treated rats. On the other hand, phenylhydrazine (10 mg/kg p.o. once a day for 8 days) decreased RBC, Hct and Hgb, and increased serum EPO concentration and kidney EPO mRNA content. Phenylhydrazine had little effect on BUN or s-CRE. 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| identifier | ISSN: 0388-1350 |
| ispartof | The Journal of Toxicological Sciences, 1996/08/25, Vol.21(3), pp.157-165 |
| issn | 0388-1350 1880-3989 |
| language | eng |
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| subjects | Anemia - blood Anemia - chemically induced Anemia - physiopathology Animals Antineoplastic Agents - toxicity Biological and medical sciences Blood Urea Nitrogen Cisplatin Cisplatin - toxicity Creatinine - blood Drug toxicity and drugs side effects treatment Erythrocyte Count - drug effects Erythropoietin - biosynthesis Erythropoietin - blood Hematocrit Hemoglobins - drug effects Immunoenzyme Techniques Kidney - drug effects Kidney - metabolism Kidney Diseases - blood Kidney Diseases - chemically induced Kidney Diseases - physiopathology Male Medical sciences Pharmacology. Drug treatments Phenylhydrazines Polymerase Chain Reaction Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Toxicity: blood Transcription, Genetic |
| title | EFFECTS OF CISPLATIN ON ERYTHROPOIETIN PRODUCTION IN RATS |
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