COMPARISON OF SEX DIFFERENCES IN GUINEA-PIG MAXIMIZATION TEST FOR DETECTION OF SKIN-SENSITIZING POTENTIAL USING OECD RECOMMENDED POSITIVE CONTROL SENSITIZERS

Both male and female guinea pigs are widely used in tests to detect the skin-sensi-tizing potential of new chemicals. The aim of the present study was to investigate the influence of the animal gender on sensitization rates, with the guinea-pig maximization test (GPMT) using OECD recommended positiv...

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Published in:Journal of toxicological sciences 1998/05/09, Vol.23(2), pp.105-111
Main Authors: NAKAMURA, Yosuke, HIGAKI, Tamaki, KATO, Hiroshi, KISHIDA, Fumio, NAKATSUKA, Iwao
Format: Article
Language:English
Subjects:
Acrolein - analogs & derivatives
Animals
Benzocaine
Benzothiazoles
Biological and medical sciences
Dermatitis, Allergic Contact - etiology
Dinitrochlorobenzene
Experimental and animal immunopathology. Animal models
Female
Guinea Pigs
Immunopathology
Irritants
Langerhans cells
Langerhans Cells - physiology
Male
Medical sciences
Sex Factors
Skin - drug effects
Skin - immunology
Thiazoles
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container_issue 2
container_start_page 105
container_title Journal of toxicological sciences
container_volume 23
creator NAKAMURA, Yosuke
HIGAKI, Tamaki
KATO, Hiroshi
KISHIDA, Fumio
NAKATSUKA, Iwao
description Both male and female guinea pigs are widely used in tests to detect the skin-sensi-tizing potential of new chemicals. The aim of the present study was to investigate the influence of the animal gender on sensitization rates, with the guinea-pig maximization test (GPMT) using OECD recommended positive control sensitizers, and the differences of the density of Langerhans cells in male and female guinea pigs. The sensitization rates of males and females challenged with HCA, MBT or benzocaine gave almost the same results. There were no statistical differences between the mean responses of males and females. These results were confirmed by rechallenge with the OECD recommended positive controls. Furthermore, the density of Langerhans cells in abdominal epidermis in males (1229±45cells/mm2) was the same as that in females (1242±89cells/mm2). These results indicate that there is no significant influence of guinea-pig gender in the assessment of skin-sensitizing potential using the GPMT.
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1880-3989
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source Free Full-Text Journals in Chemistry
subjects Acrolein - analogs & derivatives
Animals
Benzocaine
Benzothiazoles
Biological and medical sciences
Dermatitis, Allergic Contact - etiology
Dinitrochlorobenzene
Experimental and animal immunopathology. Animal models
Female
Guinea Pigs
Immunopathology
Irritants
Langerhans cells
Langerhans Cells - physiology
Male
Medical sciences
Sex Factors
Skin - drug effects
Skin - immunology
Thiazoles
title COMPARISON OF SEX DIFFERENCES IN GUINEA-PIG MAXIMIZATION TEST FOR DETECTION OF SKIN-SENSITIZING POTENTIAL USING OECD RECOMMENDED POSITIVE CONTROL SENSITIZERS
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