NO TOXICITY CAUSED BY ORGAN ACCUMULATION OF CPT-11 ON MULTIPLE INJECTIONS UNDER CLINICAL REGIMENTS IN RATS

We investigated the accumulation of CPT-11 and its metabolite(SN-38)in various organs and toxicities on multiple injections of CPT-11 under clinical regiments in SD rats. CPT-11(16.7 mg/kg equivalent to 100 mg/m2)was administered intravenously by a single injection, or by multiple injections in 1 co...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicological sciences 2000/12/25, Vol.25(5), pp.393-402
Main Authors: MIURA, Kouzou, KANEKO, Kimiyuki, KADO, Shoichi, KURITA, Akinobu, KANEDA, Norimasa, CHIBA, Katsuyoshi, KATO, Ikuo, ONOUE, Masaharu
Format: Article
Language:English
Subjects:
Rat
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the accumulation of CPT-11 and its metabolite(SN-38)in various organs and toxicities on multiple injections of CPT-11 under clinical regiments in SD rats. CPT-11(16.7 mg/kg equivalent to 100 mg/m2)was administered intravenously by a single injection, or by multiple injections in 1 course(once a week for three consecutive weeks)or 3 courses(1 course repeated 3 times at intervals of 2 weeks). There was no tendency for CPT-11 and SN-38 to accumulate in any organs regardless of the number of injections. Treatment-related changes were not observed in the general condition, body weight, hematology, biochemistry, and organ weights. Histopathological changes induced by CPT-11 were not persistent and the rats made a rapid recovery after the administrations. From these results, it is suggested that there is no toxicity caused by accumulation of CPT-11 and its active metabolite, SN-38, in organs under clinical regiments in rats.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.25.5_393