A THREE-MONTH REPEATED ORAL ADMINISTRATION STUDY OF A LOW VISCOSITY GRADE OF HYDROXYPROPYL METHYLCELLULOSE IN RATS

The toxicity of the lowest viscosity grade of hydroxiprorpyl methylcellulose (HPMC) that is currently commercially available was investigated by means of a three-month repeated oral administration study in male and female Crj:CD (SD) IGS rats at doses of 505, 1, 020 and 2, 100 mg/kg/day. Body weight...

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Bibliographic Details
Published in:Journal of toxicological sciences 1999, Vol.24(1), pp.33-43
Main Authors: OBARA, Sakae, MUTO, Hiroaki, SHIGENO, Hitoshi, YOSHIDA, Ayako, NAGAYA, Jyun-ichi, HIRATA, Mariko, FURUKAWA, Masatoshi, SUNAGA, Masao
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Biological and medical sciences
Blood Chemical Analysis
Body Weight - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
Eating - drug effects
Eye - drug effects
Female
Hypromellose Derivatives
Male
Medical sciences
Methylcellulose - analogs & derivatives
Methylcellulose - toxicity
Organ Size - drug effects
Rats
Sex Factors
Toxicity
Toxicology
Urine
Various organic compounds
Viscosity
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Summary:The toxicity of the lowest viscosity grade of hydroxiprorpyl methylcellulose (HPMC) that is currently commercially available was investigated by means of a three-month repeated oral administration study in male and female Crj:CD (SD) IGS rats at doses of 505, 1, 020 and 2, 100 mg/kg/day. Body weights of males and females in the 2, 100 mg/kg group were lower than those of the control group on and after day 28 of administration, but the differences were not statistically significant. The degree of suppression of body weight gain in males was higher than that in females. This tendency was similar to the results in other toxicity studies of HPMC that have been reported. Males in the 2, 100 mg/kg group showed a tendency (not significant) for decreased food consumption and urine volume. Examinations of general signs, hematology, blood chemistry, ophthalmology, absolute and relative organ weights, autopsy and Phistopathology revealed only a few, apparently coincidental, statistically significant differences from the control, and no evidence of any dose-dependent changes was found. It was concluded that the lowest viscosity grade of HPMC showed extremely lo1w toxicity under the conditions of this study, as has been found for higher viscosity grades.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.24.33