EFFECT OF FOOD RESTRICTION ON HEPATOTOXICITY OF CARBON TETRACHLORIDE IN RATS

Five-week-old Sprague-Dawley rats of both sexes were assigned to two types of feeding condition. One was fed ad libitum(AL)on commercial chow and another was fed a restricted amount of the chow(FR), approximately 75% of that fed in the AL condition. In each feeding condition, animals were orally adm...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicological sciences 2000/02/28, Vol.25(1), pp.33-40
Main Authors: SEKI, Makoto, KASAMA, kikuko, IMAI, Kiyoshi
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotransformation
Carbon Tetrachloride - pharmacokinetics
Carbon Tetrachloride - toxicity
Cytochrome P-450 Enzyme System - metabolism
Energy Intake
Female
Liver - drug effects
Liver - pathology
Male
Medical sciences
Miscellaneous
Rats
Rats, Sprague-Dawley
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Five-week-old Sprague-Dawley rats of both sexes were assigned to two types of feeding condition. One was fed ad libitum(AL)on commercial chow and another was fed a restricted amount of the chow(FR), approximately 75% of that fed in the AL condition. In each feeding condition, animals were orally administered carbon tetrachloride (CCl4) at levels of 0(control), 0.1 or 0.2 ml / kg 6 days a week for 8 weeks. Lesions of the liver(hepatic cellular degeneration and fibrosis)and of the kidney(proximal tubular vacuolation and glomerular sclerosis)induced by CCl4 were aggravated in the FR group. The FR-control showed a higher metabolic activity of aniline in the liver than the AL-control group. Plasma lipid-peroxide(LPO)level was higher in the AL-control group than in the FR-control group. With CCl4 0.2 ml / kg treatment however, the plasma LPO level was reversed between the AL and the FR groups. Taking together these somewhat unexpected results, it was concluded that(1)25%food restriction increases toxicity of repeatedly administered CCl4 in rats, and(2)aggravation of CCl4 toxicity may be partly due to enhanced metabolic activation of CCl4 resulting from food restriction.
ISSN:0388-1350
1880-3989
DOI:10.2131/jts.25.33