Aluminum(III) Hydrogensulfate: An Efficient Solid Acid Catalyst for the Preparation of 5-Substituted 1H-Tetrazoles

An efficient method for preparation of 5-substituted 1H-tetrazoles via [2 + 3] cycloaddition of nitriles and sodium azide is reported using aluminum(III) hydrogensulfate as an effective solid acid. This method has the advantages of good yields, simple methodology, and easy workup.

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Bibliographic Details
Published in:Synthetic communications 2011-10, Vol.41 (20), p.3053-3059
Main Authors: Sajadi, S. Mohammad, Khalaj, Mehdi, Jamkarani, Sayyed Mohammad Hosseini, Mahame, Mehdi, Kashefib, Mehrdad
Format: Article
Language:English
Subjects:
5-substituted 1H-tetrazole
[2 + 3] cycloaddition
Acids
Aluminum
Aluminum(III)
hydrogensulfate
nitrile
solid acid catalyst
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Description
Summary:An efficient method for preparation of 5-substituted 1H-tetrazoles via [2 + 3] cycloaddition of nitriles and sodium azide is reported using aluminum(III) hydrogensulfate as an effective solid acid. This method has the advantages of good yields, simple methodology, and easy workup.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2010.516861