Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

Background/Aims: An important public health issue is monitoring folate inadequacy in women of childbearing potential. The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Methods: A total...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2013-01, Vol.63 (3), p.179-185
Main Authors: Agodi, Antonella, Barchitta, Martina, Valenti, Giovanna, Quattrocchi, Annalisa, Marchese, Anna Elisa, Conti, Gea Oliveri, Fallico, Roberto, Sciacca, Salvatore, Ferrante, Margherita
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Biomarkers - blood
Cross-Sectional Studies
Diet
Dietary supplements
Erythrocytes - chemistry
Female
Folic Acid - administration & dosage
Folic Acid - blood
Folic Acid Deficiency - epidemiology
Folic Acid Deficiency - genetics
Genotype
Health policy
Homocysteine - blood
Human exposure
Humans
Mediterranean Region - epidemiology
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Methylenetetrahydrofolate Reductase (NADPH2) - metabolism
Middle Aged
Nutrition
Nutrition Assessment
Original Paper
Polymorphism, Genetic
Pregnancy
Public health
Studies
Surveys and Questionnaires
Young Adult
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Summary:Background/Aims: An important public health issue is monitoring folate inadequacy in women of childbearing potential. The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Methods: A total of 204 women were enrolled in a cross-sectional study. Folate intake was assessed by a food frequency questionnaire, and RBC folate, tHcy and MTHFR C677T genotype were determined. Results: About half of the women had a decreased RBC folate level (
ISSN:0250-6807
1421-9697
DOI:10.1159/000346962