Solvent-Controlled Copper-Catalyzed Oxidation of Benzylic Alcohols to Aldehydes and Esters

A procedure for the copper‐catalyzed selective oxidation of primary alcohols to esters and aldehydes was developed. Under solvent‐free conditions, self‐oxidative esterification and cross‐esterification of benzyl alcohols with various aliphatic alcohols proceed smoothly to give the corresponding este...

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Bibliographic Details
Published in:European journal of organic chemistry 2013-07, Vol.2013 (21), p.4503-4508
Main Authors: Zhu, Yefeng, Wei, Yunyang
Format: Article
Language:English
Subjects:
Alcohols
Aldehydes
Copper
Esterification
Oxidation
Synthetic methods
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Summary:A procedure for the copper‐catalyzed selective oxidation of primary alcohols to esters and aldehydes was developed. Under solvent‐free conditions, self‐oxidative esterification and cross‐esterification of benzyl alcohols with various aliphatic alcohols proceed smoothly to give the corresponding esters in good yields. If DMF was used as a solvent, the benzyl alcohols were selectively converted into the corresponding aldehydes in excellent yields. Depend on solvent! Under solvent‐free conditions, Cu‐catalyzed oxidative self‐esterification and cross‐esterification of benzylic alcohols with various aliphatic alcohols proceed smoothly to give the corresponding esters in good yields. If DMF is used as a solvent, the benzylic alcohols are selectively converted into the corresponding aldehydes in excellent yields. DTBP = di‐tert‐butyl peroxide.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201300668