Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis

This microreview discusses recent efforts in chemical synthesis to design divergent pathways either to access diverse natural products from a common intermediate or to produce diverse libraries of compounds reminiscent of natural products. These efforts are generally based on the development and use...

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Bibliographic Details
Published in:European journal of organic chemistry 2013-07, Vol.2013 (20), p.4195-4214
Main Authors: Serba, Christelle, Winssinger, Nicolas
Format: Article
Language:English
Subjects:
Cascade reactions
Divergent pathways
Molecular diversity
Natural products
Synthesis design
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Summary:This microreview discusses recent efforts in chemical synthesis to design divergent pathways either to access diverse natural products from a common intermediate or to produce diverse libraries of compounds reminiscent of natural products. These efforts are generally based on the development and use of powerful complexity‐generating reactions and cascade reactions. A panel of eighteen examples is used to illustrate different strategies. Strategically divergent: Designing synthetic pathways from pluripotent intermediates. Getting more molecules for your carbon.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201300201