Tröger's Base Derived Phosphanes for ­Suzuki-Miyaura and Buchwald-Hartwig Cross-Coupling Reactions

A library of bis(phosphane) ligands based on the 2,8‐substituted Tröger's base scaffold was synthesized through an efficient two‐step protocol by starting from a commercially available aniline. The new ligands proved their efficiency in palladium‐catalyzed Suzuki–Miyaura cross‐coupling reaction...

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Bibliographic Details
Published in:European journal of organic chemistry 2013-07, Vol.2013 (20), p.4233-4237
Main Authors: Pereira, Raul, Cvengroš, Ján
Format: Article
Language:English
Subjects:
Cross-coupling
Homogeneous catalysis
Ligand design
Palladium
Phosphane li­gands
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Summary:A library of bis(phosphane) ligands based on the 2,8‐substituted Tröger's base scaffold was synthesized through an efficient two‐step protocol by starting from a commercially available aniline. The new ligands proved their efficiency in palladium‐catalyzed Suzuki–Miyaura cross‐coupling reactions and Buchwald–Hartwig aminations of aryl chlorides and bromides. Easily accessible bisphosphane ligands based on the 2,8‐substituted Tröger's base scaffold are synthesized and effectively applied in palladium‐catalyzed C–C and C–N bond‐forming reactions of aryl chlorides and bromides.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201300519