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Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ–TIF2 fusion
Chromosomal translocations that involve the monocytic leukemia zinc finger (MOZ) gene are typically associated with human acute myeloid leukemia (AML) and often predict a poor prognosis. Overexpression of HOXA9, HOXA10, and MEIS1 was observed in AML patients with MOZ fusions. To assess the functiona...
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Published in: | International journal of hematology 2014, Vol.99 (1), p.21-31 |
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description | Chromosomal translocations that involve the monocytic leukemia zinc finger (MOZ) gene are typically associated with human acute myeloid leukemia (AML) and often predict a poor prognosis. Overexpression of HOXA9, HOXA10, and MEIS1 was observed in AML patients with MOZ fusions. To assess the functional role of HOX upregulation in leukemogenesis by MOZ–TIF2, we focused on bromodomain-PHD finger protein 1 (BRPF1), a component of the MOZ complex that carries out histone acetylation for generating and maintaining proper epigenetic programs in hematopoietic cells. Immunoprecipitation analysis showed that MOZ–TIF2 forms a stable complex with BRPF1, and chromatin immunoprecipitation analysis showed that MOZ–TIF2 and BRPF1 interact with HOX genes in MOZ–TIF2-induced AML cells. Depletion of BRPF1 decreased the MOZ localization on HOX genes, resulting in loss of transformation ability induced by MOZ–TIF2. Furthermore, mutant MOZ–TIF2 engineered to lack histone acetyltransferase activity was incapable of deregulating HOX genes as well as initiating leukemia. These data indicate that MOZ–TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia. We suggest that activation of BRPF1/HOX pathway through MOZ HAT activity is critical for MOZ–TIF2 to induce AML. |
doi_str_mv | 10.1007/s12185-013-1466-x |
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Overexpression of HOXA9, HOXA10, and MEIS1 was observed in AML patients with MOZ fusions. To assess the functional role of HOX upregulation in leukemogenesis by MOZ–TIF2, we focused on bromodomain-PHD finger protein 1 (BRPF1), a component of the MOZ complex that carries out histone acetylation for generating and maintaining proper epigenetic programs in hematopoietic cells. Immunoprecipitation analysis showed that MOZ–TIF2 forms a stable complex with BRPF1, and chromatin immunoprecipitation analysis showed that MOZ–TIF2 and BRPF1 interact with HOX genes in MOZ–TIF2-induced AML cells. Depletion of BRPF1 decreased the MOZ localization on HOX genes, resulting in loss of transformation ability induced by MOZ–TIF2. Furthermore, mutant MOZ–TIF2 engineered to lack histone acetyltransferase activity was incapable of deregulating HOX genes as well as initiating leukemia. These data indicate that MOZ–TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia. We suggest that activation of BRPF1/HOX pathway through MOZ HAT activity is critical for MOZ–TIF2 to induce AML.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-013-1466-x</identifier><identifier>PMID: 24258712</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cell Line, Tumor ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Disease Models, Animal ; Gene Expression ; Gene Knockdown Techniques ; Hematologic and hematopoietic diseases ; Hematology ; Histone Acetyltransferases - chemistry ; Histone Acetyltransferases - genetics ; Histone Acetyltransferases - metabolism ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Humans ; Leukemia - genetics ; Leukemia - metabolism ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - metabolism ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Mice ; Molecular Sequence Data ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Oncogene Proteins, Fusion - genetics ; Oncogene Proteins, Fusion - metabolism ; Oncology ; Original Article ; Protein Binding ; Protein Interaction Domains and Motifs</subject><ispartof>International journal of hematology, 2014, Vol.99 (1), p.21-31</ispartof><rights>The Japanese Society of Hematology 2013</rights><rights>2015 INIST-CNRS</rights><rights>The Japanese Society of Hematology 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-12a4523789330adbd871bec8c7429bbbaa6a7ee4e860a0367ac96102a0d21a8a3</citedby><cites>FETCH-LOGICAL-c426t-12a4523789330adbd871bec8c7429bbbaa6a7ee4e860a0367ac96102a0d21a8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28598588$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24258712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shima, Haruko</creatorcontrib><creatorcontrib>Yamagata, Kazutsune</creatorcontrib><creatorcontrib>Aikawa, Yukiko</creatorcontrib><creatorcontrib>Shino, Mika</creatorcontrib><creatorcontrib>Koseki, Haruhiko</creatorcontrib><creatorcontrib>Shimada, Hiroyuki</creatorcontrib><creatorcontrib>Kitabayashi, Issay</creatorcontrib><title>Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ–TIF2 fusion</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Chromosomal translocations that involve the monocytic leukemia zinc finger (MOZ) gene are typically associated with human acute myeloid leukemia (AML) and often predict a poor prognosis. Overexpression of HOXA9, HOXA10, and MEIS1 was observed in AML patients with MOZ fusions. To assess the functional role of HOX upregulation in leukemogenesis by MOZ–TIF2, we focused on bromodomain-PHD finger protein 1 (BRPF1), a component of the MOZ complex that carries out histone acetylation for generating and maintaining proper epigenetic programs in hematopoietic cells. Immunoprecipitation analysis showed that MOZ–TIF2 forms a stable complex with BRPF1, and chromatin immunoprecipitation analysis showed that MOZ–TIF2 and BRPF1 interact with HOX genes in MOZ–TIF2-induced AML cells. Depletion of BRPF1 decreased the MOZ localization on HOX genes, resulting in loss of transformation ability induced by MOZ–TIF2. Furthermore, mutant MOZ–TIF2 engineered to lack histone acetyltransferase activity was incapable of deregulating HOX genes as well as initiating leukemia. These data indicate that MOZ–TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia. We suggest that activation of BRPF1/HOX pathway through MOZ HAT activity is critical for MOZ–TIF2 to induce AML.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Disease Models, Animal</subject><subject>Gene Expression</subject><subject>Gene Knockdown Techniques</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Histone Acetyltransferases - chemistry</subject><subject>Histone Acetyltransferases - genetics</subject><subject>Histone Acetyltransferases - metabolism</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>Leukemia - genetics</subject><subject>Leukemia - metabolism</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Oncogene Proteins, Fusion - metabolism</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Protein Binding</subject><subject>Protein Interaction Domains and Motifs</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kL9uFDEQhy0EIkfgAWiQJURp4vH635YQCIkUFIrQ0FizXm9wuF0He1ckXd6BN-RJ8OkukCbSSFPMNzM_fYS8BP4WODcHBQRYxTg0DKTW7PoRWYHVijXGyMdkxVuhmDLA98izUi45B8OleUr2hBTKGhArgu9zGlOfRowT-3L8gQ5xugiZXuU0hzhRoLFQn-McPa7pkDJdh-VHGNNFmEKpMywl-Yhz6OmvOH-nn8--_bn9fX5yJOiwlJim5-TJgOsSXuz6Pvl69PH88Jidnn06OXx3yrwUemYgUCrRGNs2Dce-62u-LnjrjRRt13WIGk0IMljNkTfaoG81cIG8F4AWm33yenu3Rv-5hDK7y7Tkqb50II2uBYpXCraUz6mUHAZ3leOI-cYBdxupbivVValuI9Vd151Xu8tLN4b-38adxQq82QFYqqYh4-Rj-c9Z1VplbeXElit1tNF8L-KD3_8CM2mP2w</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Shima, Haruko</creator><creator>Yamagata, Kazutsune</creator><creator>Aikawa, Yukiko</creator><creator>Shino, Mika</creator><creator>Koseki, Haruhiko</creator><creator>Shimada, Hiroyuki</creator><creator>Kitabayashi, Issay</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2014</creationdate><title>Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ–TIF2 fusion</title><author>Shima, Haruko ; Yamagata, Kazutsune ; Aikawa, Yukiko ; Shino, Mika ; Koseki, Haruhiko ; Shimada, Hiroyuki ; Kitabayashi, Issay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-12a4523789330adbd871bec8c7429bbbaa6a7ee4e860a0367ac96102a0d21a8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Disease Models, Animal</topic><topic>Gene Expression</topic><topic>Gene Knockdown Techniques</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Histone Acetyltransferases - chemistry</topic><topic>Histone Acetyltransferases - genetics</topic><topic>Histone Acetyltransferases - metabolism</topic><topic>Homeodomain Proteins - genetics</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Humans</topic><topic>Leukemia - genetics</topic><topic>Leukemia - metabolism</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - metabolism</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Oncogene Proteins, Fusion - metabolism</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Protein Binding</topic><topic>Protein Interaction Domains and Motifs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shima, Haruko</creatorcontrib><creatorcontrib>Yamagata, Kazutsune</creatorcontrib><creatorcontrib>Aikawa, Yukiko</creatorcontrib><creatorcontrib>Shino, Mika</creatorcontrib><creatorcontrib>Koseki, Haruhiko</creatorcontrib><creatorcontrib>Shimada, Hiroyuki</creatorcontrib><creatorcontrib>Kitabayashi, Issay</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shima, Haruko</au><au>Yamagata, Kazutsune</au><au>Aikawa, Yukiko</au><au>Shino, Mika</au><au>Koseki, Haruhiko</au><au>Shimada, Hiroyuki</au><au>Kitabayashi, Issay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ–TIF2 fusion</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2014</date><risdate>2014</risdate><volume>99</volume><issue>1</issue><spage>21</spage><epage>31</epage><pages>21-31</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>Chromosomal translocations that involve the monocytic leukemia zinc finger (MOZ) gene are typically associated with human acute myeloid leukemia (AML) and often predict a poor prognosis. Overexpression of HOXA9, HOXA10, and MEIS1 was observed in AML patients with MOZ fusions. To assess the functional role of HOX upregulation in leukemogenesis by MOZ–TIF2, we focused on bromodomain-PHD finger protein 1 (BRPF1), a component of the MOZ complex that carries out histone acetylation for generating and maintaining proper epigenetic programs in hematopoietic cells. Immunoprecipitation analysis showed that MOZ–TIF2 forms a stable complex with BRPF1, and chromatin immunoprecipitation analysis showed that MOZ–TIF2 and BRPF1 interact with HOX genes in MOZ–TIF2-induced AML cells. Depletion of BRPF1 decreased the MOZ localization on HOX genes, resulting in loss of transformation ability induced by MOZ–TIF2. Furthermore, mutant MOZ–TIF2 engineered to lack histone acetyltransferase activity was incapable of deregulating HOX genes as well as initiating leukemia. These data indicate that MOZ–TIF2/BRPF1 complex upregulates HOX genes mediated by MOZ-dependent histone acetylation, leading to the development of leukemia. We suggest that activation of BRPF1/HOX pathway through MOZ HAT activity is critical for MOZ–TIF2 to induce AML.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24258712</pmid><doi>10.1007/s12185-013-1466-x</doi><tpages>11</tpages></addata></record> |
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subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Animals Biological and medical sciences Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Disease Models, Animal Gene Expression Gene Knockdown Techniques Hematologic and hematopoietic diseases Hematology Histone Acetyltransferases - chemistry Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Leukemia - genetics Leukemia - metabolism Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Mice Molecular Sequence Data Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncology Original Article Protein Binding Protein Interaction Domains and Motifs |
title | Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ–TIF2 fusion |
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