Loading…

High-dose therapy and autologous stem cell transplantation in peripheral T-cell lymphoma: treatment outcome and prognostic factor analysis

Peripheral T-cell lymphoma (PTCL) carries a poor prognosis with conventional treatment. We retrospectively analyzed data from 45 patients with PTCL who received high-dose therapy and autologous stem cell transplantation (HDT/ASCT) from 1990 to 2008 in our center. Eighteen patients underwent HDT/ASCT...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2014, Vol.99 (1), p.69-78
Main Authors: Gui, Lin, Shi, Yuan-kai, He, Xiao-hui, Lei, Ying-heng, Zhang, Hong-zhi, Han, Xiao-hong, Zhou, Sheng-yu, Liu, Peng, Yang, Jiang-liang, Dong, Mei, Zhang, Chang-gong, Yang, Sheng, Qin, Yan
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Peripheral T-cell lymphoma (PTCL) carries a poor prognosis with conventional treatment. We retrospectively analyzed data from 45 patients with PTCL who received high-dose therapy and autologous stem cell transplantation (HDT/ASCT) from 1990 to 2008 in our center. Eighteen patients underwent HDT/ASCT in complete remission to induction chemotherapy (CR1), and 27 patients underwent HDT/ASCT in other disease statuses. The median follow-up was 113.5 months (range 52.6–261.0) for surviving patients. The 5-year overall survival (OS) and progression-free survival (PFS) were 64 and 60 %, respectively. The 5-year OS for patients in CR1 and in other disease statuses was 89 and 47 %, respectively ( P  = 0.002), and 5-year PFS was 83 and 43 % ( P  = 0.007). In the subgroup excluding anaplastic large cell lymphoma, patients transplanted in CR1 also had significantly better 5-year OS (82 vs. 37 %, P  = 0.009) and PFS (82 vs. 33 %, P  = 0.008) than those transplanted in other disease statuses. Multivariate analysis showed that CR1 status was the only significant prognostic factor for OS ( P  = 0.040) and PFS ( P  = 0.040). These results support the use of HDT/ASCT consolidation in CR1 for PTCL patients. Prospective randomized trials are necessary to confirm the efficacy of this approach.
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-013-1465-y