Five-year follow-up of ^sup 11^C-PIB uptake in Alzheimer's disease and MCI

The aim of this study was to evaluate the longitudinal changes in [^sup 11^C]PIB uptake in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up. Six AD patients, ten MCI patients and eight healthy subjects underwent a [^sup 11^C]PIB PET scan at baseline and at...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2014-02, Vol.41 (2), p.283
Main Authors: Kemppainen, N M, Scheinin, N M, Koivunen, J, Johansson, J, Toivonen, J T, Någren, K, Rokka, J, Karrasch, M, Parkkola, R, Rinne, J O
Format: Article
Language:English
Subjects:
Alzheimer's disease
Cognitive therapy
Medical imaging
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Summary:The aim of this study was to evaluate the longitudinal changes in [^sup 11^C]PIB uptake in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up. Six AD patients, ten MCI patients and eight healthy subjects underwent a [^sup 11^C]PIB PET scan at baseline and at 2 and 5 years. The clinical status of the MCI patients was evaluated every 6 months. The MCI group showed a significant increase in [^sup 11^C]PIB uptake over time (p
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-013-2562-0