New Dihydroquinolinone Toxic to Artemia salina Produced by Penicillium sp. NTC-47

Penicillium sp. NTC-47, which had been isolated from a soil sample, produced novel dihydroquinolinones when cultured with okara (the insoluble residue of whole soybean). These metabolites, 1 and 2, were crystalline products with molecular formulas of C 17 H 17 NO 5 and C 17 H 17 NO 4 , respectively....

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1997, Vol.61 (5), p.914-916
Main Authors: Hayashi, Hideo, Nakatani, Tadashi, Inoue, Yoshiki, Nakayama, Mitsuru, Nozaki, Hiroshi
Format: Article
Language:English
Subjects:
Applied microbiology
Biological and medical sciences
brine shrimp
dihydroquinolinone
Fundamental and applied biological sciences. Psychology
Microbiology
Miscellaneous
Penicillium
Penicillium sp
toxicity
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Summary:Penicillium sp. NTC-47, which had been isolated from a soil sample, produced novel dihydroquinolinones when cultured with okara (the insoluble residue of whole soybean). These metabolites, 1 and 2, were crystalline products with molecular formulas of C 17 H 17 NO 5 and C 17 H 17 NO 4 , respectively. The structure of 1 was established to be 3-methoxy-4,5-dihydroxy-4-(4′-methoxyphenyl)-quinolinone by spectroscopic evidence and by an X-ray crystal-lographic analysis. Spectral data indicated the structure of 2 to be 5-deoxy-l. Compound 1 demonstrated toxicity against brine shrimp with an LC 50 value of 20μg/ml, but 2 exhibited no activity at a dose of 100 μg/ml.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.61.914