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Emergence of minority alleles during treatment was detected in only 1 of 23 cases defined as being artemisinin resistant. [...]daily genotyping did not alter the final outcome classification in any recurrent cases. CHIKV is a highly cytopathic virus that rapidly kills infected cells. [...]cell viabi...

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Bibliographic Details
Published in:Indian journal of medical microbiology 2014-01, Vol.32 (1), p.107-109
Main Author: Desikan, Prabha
Format: Article
Language:English
Subjects:
Disease control
Drug resistance
FDA approval
Influenza
Malaria
Mosquitoes
Nanoparticles
Patients
Proteins
Studies
Vaccines
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Summary:Emergence of minority alleles during treatment was detected in only 1 of 23 cases defined as being artemisinin resistant. [...]daily genotyping did not alter the final outcome classification in any recurrent cases. CHIKV is a highly cytopathic virus that rapidly kills infected cells. [...]cell viability of HuH-7 cells infected with CHIKV in the presence of compounds was determined by measuring metabolic reduction of resazurin to identify inhibitors of CHIKV-associated cell death.\n A study retrospectively determined, for the period 2007 to 2009, the proportion of RMR among Mycobacterium tuberculosis (MTB) isolates, that were tested for both RIF and INH, using the gold standard of culture-based phenotypic drug susceptibility testing (DST). On the basis of data from two Phase IIb trials (i.e. well-controlled trials to evaluate the efficacy and safety of drugs in patients with a disease or condition to be treated, diagnosed or prevented), the Food and Drug Administration (FDA) approved use of bedaquiline under the provisions of the accelerated approval regulations for "serious or life-threatening illnesses" (21CFR314.500) (Cox EM.
ISSN:0255-0857
1998-3646
DOI:10.4103/0255-0857.124362