Levodopa inhibits habit-learning in Parkinson’s disease

Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa....

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Bibliographic Details
Published in:Journal of Neural Transmission 2014-02, Vol.121 (2), p.147-151
Main Authors: Fuhrer, Hannah, Kupsch, Andreas, Hälbig, Thomas D., Kopp, Ute A., Scherer, Peter, Gruber, Doreen
Format: Article
Language:English
Subjects:
Adult
Aged
Antiparkinson Agents - adverse effects
Association Learning - drug effects
Choice Behavior - drug effects
Cues
Ecosystem
Female
Humans
Learning Disorders - chemically induced
Learning Disorders - diagnosis
Levodopa - adverse effects
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neurology and Preclinical Neurological Studies - Short communication
Neurosciences
Parkinson Disease - drug therapy
Parkinson's disease
Psychiatry
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Summary:Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-013-1081-2